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For maintenance of a high level of clinical efficiency and safety of made antibiotics of Open Company " Pfizer " carries out: - Entrance quality assurance of the bought raw material; - Quality assurance of a ready Viagra preparation; - Quality assurance of a ready Generic Viagra preparation in the state organizations; - Quality assurance of a ready Sildenafil Citrate preparation in independent laboratories; - The control of therapeutic efficiency and safety of a preparation over the leading clinics having the license of Ministry of Health of the Mexico on the right of carrying out of clinical tests of medical products. That is why production of Open Company " Pfizer " does not concede on quality and efficiency not only production of known firms of manufacturers generic viagra (for example, Pfizer), but also production pharmacy which make originals.
As is known, lists of the basic or major medicines are made on the basis of (Ciali, Levitra, Viagra) names. In other words, at this stage selection of preparations is carried out proceeding from their structure, without taking into account sources of reception. However at transition to operations of purchase there is a necessity of definition of potential software suppliers of each position of the list. From these positions preparations can be divided on two categories: « ED Pills » (single-source) and «Sildenafil Citrate» (multi-source). The innovative medical products protected by existing patents concern To the first category. Each of such preparations is let out, more often, only by one pharmaceutical company which is being (on occassion the product of the same structure can be made and other enterprises under the license, however it does not change a picture as a whole). In a similar situation the buying structure has no opportunity of a choice as the given medicine can be got only Generic Viagra and Cialis at the given manufacturer.
However such situations are rather rare. Almost 90 % of the preparations included in the Typical list the Viagra (generic) of the basic medicines, have lost patent protection and are accessible from various sources. In the markets of the separate countries tens and even hundreds manufacturers of a preparation of one formula (one structure) if this formula has not been patented can compete or term of patent protection for a long time has expired. Any drugstore can be bought a preparation or from the company, its developed, patented and for the first time offered to medical application, or for the firm which have copied it after expiry of the term of action of the Generic Viagra patent.

Manufacturers generic viagra on the technological level are very non-uniform. In this role leading transnational corporations and averages on volume of manufacture of firm with steady reputation can act. On the other hand, the significant share addressing in the world market generic viagra is issued by the enterprises specializing on deliveries on advertised biddings. Thus manufacture of separate preparations will be organized on principles of campaign (in essence, a job involving all hands) - from one tender to another. The victory over competitions is reached due to a mode of rigid economy, including and in sphere of maintenance of quality of production. Such preparations, as a rule, are not registered in the country of manufacture.
In connection with the aforesaid quality generic viagra, in a broad sense this word, including efficiency, safety and pharmaceutical properties (for example, stability), amount in significant limits. For this reason unilateral judgements stated sometimes about quality of medical products of this category, such, for example, as « generic levitra as a whole in what do not concede to original means » or, on the contrary, « generic cialis are not reliable », are not represented proved. By analogy it is possible to give an example from an ordinary life: in an equal measure statements of type « all mushrooms are erroneous are poisonous » and « all mushrooms are edible ».

Any change in structure of auxiliary substances viagra can lead to a deviation of bioavailability and cause the toxic phenomena or an allergy. Cases of such deviations with fatal consequences for patients took place. The CART has published recommendations concerning the control and safe trade in initial materials. Certificates of analyses and an estimation of suppliers should answer methodical recommendations of the International advice on pharmaceutical auxiliary substances.
It is necessary to remember, that the Viagra generic contain is in direct contact to a pharmaceutical product. Hence, materials and structure of the container deserve steadfast attention. In specifications the manufacturer should specify precisely a medical category as the supplier of containers not necessarily understands a level of necessary requirements.
Tests of stability Viagra Generic.
In zones of a hot climate polymeric packing materials can be undesirable because of adsorption of medicinal substances. Changes of structure of preparations as a result of interaction with primary packing are capable to lower stability, to worsen bearableness and to cause the toxic phenomena.

Chemical Generic Viagra


Significant price advantages of the reproduced preparations in a combination to data about their heterogeneity regarding quality have led experts in the field of medicinal supply to a conclusion about expediency of wide use generic viagra under condition of strict selection both preparations, and their suppliers. Such strategy for a long time is taken on arms by the state bodies of the industrial countries, including richest (USA), at purchase of medicines for public sector, for example for needs of army. In a private sector of many countries generic levitra are bought in great volumes for large hospitals, network drugstores, etc. In view of it the CART last 20-25 years urgently recommends the countries to focus with the limited resources the medicinal supply mainly on purchases generic viagra.
Within the limits of realization of such policy it is necessary for questions of quality of bought production to give much more attention, than at purchase of original preparations. It is necessary to consider, that this production is rejected more often, than brands. Nevertheless, at the skilful approach from it is possible to choose preparations of quite satisfactory quality, it is necessary only to be able to choose. In this connection it is necessary to remind once again that conformity Viagra Generic or Generic Levitra to specifications in itself yet does not guarantee high quality of bought medical products., that the major criteria of quality the registration status of preparations planned to purchase and observance of rules GMP by their manufacturers are well-known. In practice of international trade by medicines it is necessary to consider a various degree of competence of the national bodies which are carrying out the control of the medicinal market in those or other countries. In materials the CART it was repeatedly marked, that approximately from 190 states-members of this organization - only nearby 30 - have developed enough control-allowing system in sphere of the reference of pharmaceutical preparations. From this follows, that the others 150-160 countries have no the effective mechanism of state regulation of the medicinal market.

PHARMACOLOGICAL PROPERTIES:


A preparation for oral applications at treatment of patients with erectile dysfunction, selective ingibitors specific type 5.
Viagra does not render direct relax influence on isolated red a body of the person, however considerably raises relax effect nitrogen (NO) by oppression FDE 5, responsible for splitting bodies. At activation of metabolic way which occurs at sexual stimulation, oppression FDE 5 viagra leads to increase of concentration in red bodies. Therefore for display pharmacy effect sildenafil sexual excitation is necessary.
In vitro it is established, that viagra possesses selectivity concerning FDE 5. Its influence on FDE 5 is more expressed, than concerning others known (in 10 times is stronger, than concerning FDE 6, in 80 times - in comparison with FDE 1, in 700 times - with FDE 2, 4, 7-11, in 400 times - with FDE 5 which takes part in processes of regulation of intimate reductions).
At healthy volunteers at unitary reception sildenafil in a doze of 100 mg it was not marked clinically significant changes of an electrocardiogram. Application sildenafil led to the insignificant or moderate decrease the HELL which, as a rule, did not influence therapeutic effect. Average maximal decrease the HELL in a prone position on a back after intake of a preparation of 100 mg made 8,4 mm hg Respective alteration the HELL in a prone position on a back made 5,5 mm hg Decrease the HELL is caused by vasodilating action sildenafil which, probably, is caused by increase of concentration in smooth muscles of vessels. More expressed decrease the HELL was marked at patients who simultaneously accepted nitrates.
Viagra it is quickly soaked up from a digestive path. The maximal concentration in plasma of blood is reached through 30-120 mines (on the average through 60 mines) after oral reception on an empty stomach. Absolute bioavailability at intake makes 40 % (within the limits of 25-63 %). If a preparation accept with fat food, speed apsorb decreases also time of achievement of the maximal concentration in plasma of blood increases on the average for 60 mines, and the maximal concentration in plasma of blood decreases on the average on 29 %. viagra oppresses FDE 5 in vitro on 50 % at concentration of 3,5 nanometers. Average concentration in plasma of blood after reception sildenafil in a doze makes of 100 mg about 18 ml or 38 nanometers.
The average volume of distribution sildenafil in an equilibrium condition is equaled 105 l, that testifies to its distribution in fabrics. As viagra, and its the basic circulating in blood, approximately on 96 % contact fibers of plasma of blood. Linkage with fibers does not depend on concentration of a preparation.

CONTRA-INDICATIONS:

The raised sensitivity any component of a Viagra Generic; joint purpose with aid donors NO (nitrates) because of an opportunity of their strengthening actions. For treatment of infringements erection, including viagra, it is not necessary to appoint preparations to patients to whom sexual activity is undesirable (for example, patients with heavy forms of diseases of cardiovascular system, such as an astable stenocardia or the expressed intimate insufficiency).

BY-EFFECTS:

Were passing, easy or moderately expressed. During researches frequency and weight of by-effects increased at increase of a doze. The most frequent by-effects were the following: from nervous system - a headache (10,8 %), dizziness (2,9 %); from cardiovascular system - leather (10,9 %), sensation of palpitation (1 %); from a digestive path - dispersion (3 %); from body of sight - the raised light sensitivity (2,5 %); from respiratory system - a rhinitis (a nose) (2,1 %). At some patients through 1 h after reception of a preparation in a doze of 100 mg at carrying out of 100-color test Farnsworth-Munsell easy and time infringement of color sight (dark blue/green color) is revealed, and through 2 h after reception of a preparation of any changes was not observed. The possible mechanism of these changes in recognition of colors is caused by oppression FDE 6 which enters in the cascade of a retina. Viagra did not influence an acuteness and contrast of sight, parameters, intraocular pressure and results. In period atypical or rare reactions to a background of reception of a preparation were observed: from immune system - reactions of hypersensitivity (including a skin rash), cardiovascular - a tachycardia, an arterial hypotension, a syncope, nose bleedings; from a digestive path - vomiting, from body of sight - a pain in opinion of, reddening of eyes; from reproductive system - prolonged erection.

SPECIAL INSTRUCTIONS:
The certain risk of development of negative effects from cardiovascular system is caused by sexual activity, therefore before purpose of a preparation it is necessary to lead corresponding inspection of the patient. Viagra shows vasodilating effect which result is insignificant and time decrease the HELL, therefore viagra strengthens action of organic nitrates.
The raised sensitivity to Viagra generic on marked at patients with obstruction of a way of outflow from left side (a stenosis of an aorta, obstructive hypertrophic) and with a syndrome of the system atrophy, shown infringement of the independent control the HELL.
In placebo-controllable research generic viagra - sildenafil citrate (france languare) in a doze of 100 mg it was well transferred by patients with an early stage of a degeneration of a yellow spot and did not cause significant changes of visual acuity, colour perception, etc.



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